Structure of PDB 6w4c Chain A

Receptor sequence
>6w4cA (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
MPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYP
RMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSL
GTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMG
YKAIFVTVDTPYLGNRLDDVRNRFKNFGLAAYVAKAIDPSISWEDIKWLR
RLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLP
EIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGE
KGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRK
3D structure
PDB6w4c Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y132 D160 H260
Catalytic site (residue number reindexed from 1) Y131 D159 H234
Enzyme Commision number 1.1.3.15: (S)-2-hydroxy-acid oxidase.
1.2.3.5: glyoxylate oxidase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0047969 glyoxylate oxidase activity
Biological Process
GO:0001561 fatty acid alpha-oxidation
GO:0006545 glycine biosynthetic process
GO:0006979 response to oxidative stress
GO:0008652 amino acid biosynthetic process
GO:0046296 glycolate catabolic process
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6w4c, PDBe:6w4c, PDBj:6w4c
PDBsum6w4c
PubMed33955740
UniProtQ9UJM8|HAOX1_HUMAN 2-Hydroxyacid oxidase 1 (Gene Name=HAO1)

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