Structure of PDB 6w2b Chain A

Receptor sequence
>6w2bA (length=544) Species: 9606 (Homo sapiens) [Search protein sequence]
GSQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTI
MAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIA
SYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLH
STSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKG
VKTSGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLET
GVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSF
VSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFF
AIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITC
FFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCR
DVKEMLGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYW
SIILGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP
3D structure
PDB6w2b Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
ChainA
Resolution4.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RFS A Y95 A96 D98 A169 F335 F341 S438 T439 G442 T497 V501 Y22 A23 D25 A96 F262 F268 S365 T366 G369 T424 V428
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:6w2b, PDBe:6w2b, PDBj:6w2b
PDBsum6w2b
PubMed32618269
UniProtP31645|SC6A4_HUMAN Sodium-dependent serotonin transporter (Gene Name=SLC6A4)

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