Structure of PDB 6w17 Chain A

Receptor sequence
>6w17A (length=380) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
ASFNVPIIMDNGTGYSKLGYAGNDAPSYVFPTVIATRATEDLDFFIGNDA
LKKASAGYSLDYPIRHGQIENWDHMERFWQQSLFKYLRCEPEDHYFLLTE
PPLNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLT
GTVVDSGDGVTHIIPVAEGYVIGSSIKTMPLAGRDVTYFVQSLLRDRNEP
SLKTAERIKEECCYVCPDIVKEFSRFDREPDRYLKYASSTTIDVGFERFL
APEIFFNPEIASFLTPLPELVDNVVQSSPIDVRKGLYKNIVLSGGSTLFK
NFGNRLQRDLKRIVDERIHRSEMLSGAKSGGVDVNVISHKRQRNAVWFGG
SLLAQTPEFGSYCHTKADYEEYGASIARRY
3D structure
PDB6w17 Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state.
ChainA
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G13 T14 Y16 K18 G187 D188 K241 E242 G335 S336 L338 F339 G12 T13 Y15 K17 G157 D158 K209 E210 G295 S296 L298 F299
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0006897 endocytosis
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0044396 actin cortical patch organization
GO:0090135 actin filament branching
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0030479 actin cortical patch
GO:0032153 cell division site
GO:0051285 cell cortex of cell tip

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6w17, PDBe:6w17, PDBj:6w17
PDBsum6w17
PubMed32839613
UniProtP32390|ARP3_SCHPO Actin-related protein 3 (Gene Name=act2)

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