Structure of PDB 6w0u Chain A

Receptor sequence
>6w0uA (length=138) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
GIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRW
PVKTVHTDNGSNFTSTTVKAACEWAGIKQEFGIPSMNKELKKIIGQVRDQ
AEHLKTAVQMAVFIHNKKRKGGIGGYSAGERIVDIIAT
3D structure
PDB6w0u HIV Integrase core domain in complex with inhibitor
ChainA
Resolution2.19 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S0Y A Q95 Y99 L102 T125 A129 Q37 Y41 L44 T67 A71
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6w0u, PDBe:6w0u, PDBj:6w0u
PDBsum6w0u
PubMed
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

[Back to BioLiP]