Structure of PDB 6vzw Chain A

Receptor sequence

>6vzwA (length=402) Species: 10090 (Mus musculus)

KKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVME
MKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADW
GDLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYIS
KPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLD
EICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRG
IEDVIIKTLISAHPVIKHNYHTCFPTLNSACFEILGFDILLDRKLKPWLL
EVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGRF
LQQCPNREIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDK
FF

3D structure

• PDB: 6vzw Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 6.3.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	2TI	A	C179 Q180 R219 L239 R241 N264 Y265 S266 K283 E359 N361 H362 S363 P364 S365 K377	C123 Q124 R163 L183 R185 N208 Y209 S210 K227 E301 N303 H304 S305 P306 S307 K319
BS02	ADP	A	K125 I172 K174 C179 G181 I184 Q202 Y204 I205 K215 D217 T263 N264 L358 E359	K69 I116 K118 C123 G125 I128 Q146 Y148 I149 K159 D161 T207 N208 L300 E301
BS03	MG	A	D346 E359	D288 E301
BS04	MG	A	C179 E359 N361	C123 E301 N303

Gene Ontology

Biological Process

• GO:0036211 protein modification process

External links

• PDB: RCSB:6vzw, PDBe:6vzw, PDBj:6vzw
• PDBsum: 6vzw
• PubMed: 32747782
• UniProt: A4Q9E8|TTLL6_MOUSE Tubulin polyglutamylase TTLL6 (Gene Name=Ttll6)