Structure of PDB 6vzr Chain A

Receptor sequence

>6vzrA (length=400) Species: 10090 (Mus musculus)

KKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVME
MKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADW
GDLQTYSRTRKNKTYICKPDSGARGRGIFITRSVKEIKPGEDMICQLYIS
KPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLD
EICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRG
IEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPW
LLEVNISPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRG
RFLQQEIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFF

3D structure

• PDB: 6vzr Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
• Chain: A
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 6.3.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	2TI	A	A179 R180 R219 L239 R241 N264 Y265 S266 K283 E359 N361 I362 S363 P364 S365 K377	A123 R124 R163 L183 R185 N208 Y209 S210 K227 E303 N305 I306 S307 P308 S309 K321
BS02	ADP	A	K125 I172 K174 A179 R180 G181 I184 Q202 Y204 I205 K215 D217 T263 N264 L358 E359	K69 I116 K118 A123 R124 G125 I128 Q146 Y148 I149 K159 D161 T207 N208 L302 E303
BS03	MG	A	E359 N361	E303 N305
BS04	MG	A	D346 E359	D290 E303

Gene Ontology

Biological Process

• GO:0036211 protein modification process

External links

• PDB: RCSB:6vzr, PDBe:6vzr, PDBj:6vzr
• PDBsum: 6vzr
• PubMed: 32747782
• UniProt: A4Q9E8|TTLL6_MOUSE Tubulin polyglutamylase TTLL6 (Gene Name=Ttll6)