Structure of PDB 6vwo Chain A

Receptor sequence
>6vwoA (length=383) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
AAWVVGIDQTLVDIEAKVDDEFIERYGLSAGHSLVIEDDVAEALYQELKQ
KNLITHQFAGGTIGNTMHNYSVLADDRSVLLGVMCSNIEIGSYAYRYLCN
TSSRTDLNYLQGVDGPIGRCFTLIGESGERTFAISPGHMNQLRAESIPED
VIAGASALVLTSYLVRCKPGEPMPEATMKAIEYAKKYNVPVVLTLGTKFV
IAENPQWWQQFLKDHVSILAMNEDEAEALTGESDPLLASDKALDWVDLVL
CTAGPIGLYMAGFTEDEAKRKTQHPLLPGAIAEFNQYEFSRAMRHKDCQN
PLRVYSHIAPYMGGPEKIMNTNGAGDGALAALLHDITANSYHRSNVKFTW
LTYSSLAQVCKYANRVSYQVLNQHSPRLTRGLP
3D structure
PDB6vwo ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation.
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.73: inosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N254 T284 G286 G289 L290 M344 I350 A356 G357 S405 L409 N222 T252 G254 G257 L258 M312 I318 A324 G325 S367 L371
BS02 GMP A Q41 L43 D45 S65 G93 T94 C152 I166 Y195 Q9 L11 D13 S33 G61 T62 C120 I134 Y163
BS03 GMP A L275 D276 V278 H327 L243 D244 V246 H295
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008906 inosine kinase activity
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0097216 guanosine tetraphosphate binding
GO:0106366 guanosine kinase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0016310 phosphorylation
GO:0032263 GMP salvage
GO:0032264 IMP salvage

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Molecular Function
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Biological Process
External links
PDB RCSB:6vwo, PDBe:6vwo, PDBj:6vwo
PDBsum6vwo
PubMed32857952
UniProtP0AEW6|INGK_ECOLI Guanosine-inosine kinase (Gene Name=gsk)

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