Structure of PDB 6vve Chain A

Receptor sequence

>6vveA (length=283) Species: 446 (Legionella pneumophila) [Search protein sequence]

PKINKIVNGTDLTPHYLSEPNKEFKIYRYNNEVYAVRFENDEPMDYVLMW
KSHKDYKELGKGEQGTVYEKTEDKAMKVSRGRHPREFYEEINLHIIEQQF
FLKYHGIQEHFVLGLWNIKNEENVYFYMPKINAIPINKKIDQPKIEEFVL
ALKELNDAGYWHPDLANNPYHISPQNLIATEEMVKTIDLDGGFRYDKGRV
DELSRKSLVYGKDQWLYVYNFIYPPTDEEDHRIDWRVPIEKWYENNRDES
LSDNPHTLLRFYHEGLISLPKKLAHDLHETILE

3D structure

PDB

6vve ALegionellaeffector kinase is activated by host inositol hexakisphosphate.

Chain

Resolution

1.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	IHP	A	H37 Y38 R50 W72 S74 H75 K76 K107 T108 K111 K156	H15 Y16 R28 W50 S52 H53 K54 K70 T71 K74 K119	MOAD: Kd=315uM
BS02	ADP	A	G97 V104 K114 M165 I168 N213 I224 D225	G60 V67 K77 M128 I131 N176 I187 D188
BS03	MN	A	G99 Q101 K114	G62 Q64 K77

External links

PDB	RCSB:6vve, PDBe:6vve, PDBj:6vve
PDBsum	6vve
PubMed	32229585
UniProt	Q5ZSB6

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