Structure of PDB 6vuj Chain A

Receptor sequence
>6vujA (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
SNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB6vuj Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors.
ChainA
Resolution1.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RLY A W81 P82 Q85 P86 V87 D88 L92 Y97 C136 Y139 N140 I146 W39 P40 Q43 P44 V45 D46 L50 Y55 C94 Y97 N98 I104 MOAD: ic50=35.2uM
External links
PDB RCSB:6vuj, PDBe:6vuj, PDBj:6vuj
PDBsum6vuj
PubMed32120339
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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