Structure of PDB 6vu6 Chain A

Receptor sequence

>6vu6A (length=409) Species: 888807 (Streptococcus sanguinis SK1 = NCTC 7863) [Search protein sequence]

TDTTPPTITLPQEVIAYRGEEFEFFVETTDDSGRVNRVIVRNIEGADNST
YLDPNWIRYSTDNLSVPGNATPANPLRTRVYGIVPINHGVGPGDRYTKYV
RAEDAAGNITALVDKQSERFVLVIRPQTEKYTPQVPTLTYVQNANSLTQT
DKDAVIAAVKSANPNLPATSTYSVSENGTVTITYPDGSTDTIAAAQTVDT
DRVAPVFVDEGRDYIFYRGEEGTAELHFYDNSGKITNVNFAGDLAASSTY
NTLLGLGFTFNTPNINNPNNATEQNPLVTTIRGTIPKSLPAGPGGKYTFK
VRATDASGLTSEAKIFRIVFANQTDKYTPNNPGSLTGVLNPQQLSTSEKT
AIEEKVRAANTGNLPNNVQYVVNNDGSVTVIYPDDTPASRSRDTITADRT
VQDLRPRNS

3D structure

PDB

6vu6 Tandem sialoglycan-binding modules in a Streptococcus sanguinis serine-rich repeat adhesin create target dependent avidity effects.

Chain

Resolution

2.1 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GAL	A	Y350 D365	Y99 D114
BS02	SIA	A	D304 G344 R346 Y347 T348 K349	D53 G93 R95 Y96 T97 K98
BS03	SIA	A	S499 T500 K547 T549	S248 T249 K296 T298
BS04	CA	A	D253 T255 D281 D282 D355	D2 T4 D30 D31 D104
BS05	CA	A	T379 Y382 D441	T128 Y131 D190
BS06	CA	A	D452 V454 D481 N482 D556	D201 V203 D230 N231 D305
BS07	CA	A	T575 Y578 D644	T324 Y327 D393

External links

PDB	RCSB:6vu6, PDBe:6vu6, PDBj:6vu6
PDBsum	6vu6
PubMed	32820052

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