Structure of PDB 6vta Chain A

Receptor sequence
>6vtaA (length=181) Species: 588 (Providencia stuartii) [Search protein sequence]
GSHMGIEYRSLHTSQLTLSEKEALYDLLIEGFEGDFSHDDFAHTLGGMHV
MAFDQQKLVGHVAIIQRHMALDNTPISVGYVEAMVVEQSYRRQGIGRQLM
LQTNKIIASCYQLGLLSASDDGQKLYHSVGWQIWKGKLFELKQGSYIRSI
EEEGGVMGWKADGEVDFTASLYCDFRGGDQW
3D structure
PDB6vta Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2') enzymes.
ChainA
Resolution1.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.59: gentamicin 2'-N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A G28 F29 M81 V83 R88 R89 G91 G93 R94 S114 S116 D118 K121 L122 Y123 G31 F32 M84 V86 R91 R92 G94 G96 R97 S117 S119 D121 K124 L125 Y126
BS02 AKN A F29 D32 D37 E79 A80 S114 S116 D117 W178 F32 D35 D40 E82 A83 S117 S119 D120 W181
Gene Ontology
Molecular Function
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0047921 aminoglycoside 2'-N-acetyltransferase activity
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6vta, PDBe:6vta, PDBj:6vta
PDBsum6vta
PubMed34078922
UniProtQ52424|AAC2_PROST Aminoglycoside 2'-N-acetyltransferase (Gene Name=aac)

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