Structure of PDB 6vsw Chain A

Receptor sequence
>6vswA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW
EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVR
MCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSE
DEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA
KLPPKGKLRSLCSQHVERLQIFQHLHPI
3D structure
PDB6vsw Optimization and biological evaluation of thiazole-bis-amide inverse agonists of ROR gamma t.
ChainA
Resolution3.202 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RG7 A Q286 W317 C320 H323 L324 M365 F377 F378 F388 I397 I400 H479 Q22 W53 C56 H59 L60 M101 F113 F114 F124 I133 I136 H215 BindingDB: Kd=2.0nM,IC50=28nM,EC50=109nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vsw, PDBe:6vsw, PDBj:6vsw
PDBsum6vsw
PubMed32336498
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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