Structure of PDB 6vro Chain A

Receptor sequence
>6vroA (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
VPPADQEKLFIQKLRQCCVLFSDLKWKEVKRAALSEMVEYITHNRNVITE
PIYPEVVHMFAVNMFRTLTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKK
YIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNI
FYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKV
KSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNE
LEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMS
LISDNAAKILPIMFPSLYR
3D structure
PDB6vro A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K183 H187 Y190 L194 R197 R201 E226 S230 N233 G234 F235 A236 K240 H243 P265 Q266 K126 H130 Y133 L137 R140 R144 E169 S173 N176 G177 F178 A179 K183 H186 P208 Q209
Gene Ontology
Molecular Function
GO:0019888 protein phosphatase regulator activity
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0000159 protein phosphatase type 2A complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vro, PDBe:6vro, PDBj:6vro
PDBsum6vro
PubMed32195664
UniProtQ13362|2A5G_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (Gene Name=PPP2R5C)

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