Structure of PDB 6vr3 Chain A

Receptor sequence
>6vr3A (length=177) Species: 588 (Providencia stuartii) [Search protein sequence]
GIEYRSLHTSQLTLSEKEALYDLLIEGFEGDFSHDDFAHTLGGMHVMAFD
QQKLVGHVAIIQRHMALDNTPISVGYVEAMVVEQSYRRQGIGRQLMLQTN
KIIASCYQLGLLSASDDGQKLYHSVGWQIWKGKLFELKQGSYIRSIEEEG
GVMGWKADGEVDFTASLYCDFRGGDQW
3D structure
PDB6vr3 Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2') enzymes.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.59: gentamicin 2'-N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NTL A F29 D32 D37 M81 S114 E148 E149 D176 W178 F28 D31 D36 M80 S113 E147 E148 D175 W177
BS02 COA A F29 M81 V82 V83 R88 R89 G91 G93 R94 A115 S116 Y123 F28 M80 V81 V82 R87 R88 G90 G92 R93 A114 S115 Y122
Gene Ontology
Molecular Function
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0047921 aminoglycoside 2'-N-acetyltransferase activity
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6vr3, PDBe:6vr3, PDBj:6vr3
PDBsum6vr3
PubMed34078922
UniProtQ52424|AAC2_PROST Aminoglycoside 2'-N-acetyltransferase (Gene Name=aac)

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