Structure of PDB 6vpo Chain A

Receptor sequence
>6vpoA (length=422) Species: 9823 (Sus scrofa) [Search protein sequence]
RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSFNTFFSETGAGKH
VPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIG
KEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDY
GKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYD
ICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVP
YPRAHFPLATYAPVISAQLSVAEITNACFEPANQMVKCDPRHGKYMACCL
LYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGD
LAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGE
FSEAREDMAALEKDYEEVGVDS
3D structure
PDB6vpo The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding.
ChainA
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A G10 Q11 A12 Q15 E71 D98 N101 S140 G143 T145 I171 Y224 N228 G9 Q10 A11 Q14 E60 D87 N90 S129 G132 T134 I160 Y213 N217
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0031514 motile cilium

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Cellular Component
External links
PDB RCSB:6vpo, PDBe:6vpo, PDBj:6vpo
PDBsum6vpo
PubMed31958056
UniProtP02550|TBA1A_PIG Tubulin alpha-1A chain (Gene Name=TUBA1A)

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