Structure of PDB 6vpm Chain A

Receptor sequence
>6vpmA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
MSYSYDAPSDFINFSSKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFI
LALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYL
ILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIK
PENLLLGSAGELKIADFGWSVHAPTTLCGTLDYLPPEMIEGRMHDEKVDL
WSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISR
LLKHNPSQRPMLREVLEHPWITANSSK
3D structure
PDB6vpm Redox priming promotes Aurora A activation during mitosis.
ChainA
Resolution1.58 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D256 K258 E260 N261 D274 T292
Catalytic site (residue number reindexed from 1) D148 K150 E152 N153 D166 T180
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A G140 K162 E211 Y212 A213 L263 G32 K54 E103 Y104 A105 L155
BS02 R74 A L289 C290 M300 I301 H306 L177 C178 M188 I189 H194
BS03 MG A S7 E175 H176 S2 E67 H68
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:6vpm, PDBe:6vpm, PDBj:6vpm
PDBsum6vpm
PubMed32694171
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA);
Q9ULW0

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