Structure of PDB 6vpi Chain A

Receptor sequence
>6vpiA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
SYSYDAPSDFINFSRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILAL
KVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILE
YAPLGTVYRELQKLSKFDEQRTATYITELANALSYVHSKRVIHRNIKPEN
LLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVD
LWSLGVLVYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLIS
RLLKHNPSQRPMLREVLEHPWITANSSK
3D structure
PDB6vpi Redox priming promotes Aurora A activation during mitosis.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N256 K258 E260 N261 D274 T292
Catalytic site (residue number reindexed from 1) N145 K147 E149 N150 D163 T181
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A L139 G140 G142 V147 A160 K162 E211 A213 L263 L28 G29 G31 V36 A49 K51 E100 A102 L152
BS02 MG A N261 D274 N150 D163
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6vpi, PDBe:6vpi, PDBj:6vpi
PDBsum6vpi
PubMed32694171
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA);
Q9ULW0

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