Structure of PDB 6vpf Chain A

Receptor sequence
>6vpfA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSASMMGLLTNLADRELVHM
INWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPN
LLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSG
VYTFSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLL
ILSHIRHMSNKGMEHLYSMKSKNVVPSYDLLLEMLD
3D structure
PDB6vpf Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 53Q A L346 A350 D351 W383 L387 I424 G521 H524 L525 V533 P535 L39 A43 D44 W76 L80 I117 G212 H215 L216 V224 P226
External links
PDB RCSB:6vpf, PDBe:6vpf, PDBj:6vpf
PDBsum6vpf
PubMed35575456
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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