Structure of PDB 6voy Chain A

Receptor sequence

>6voyA (length=276) Species: 11927,273057

PSPAELHSFTHCGQTALTLQGATTTEASNILRSCHACRKNNPQHQMPRGH
IRRGLLPNHIWQGDITHFKYKNTLYRLHVWVDTFSGAISATQKRKETSSE
AISSLLQAIAYLGKPSYINTDNGPAYISQDFLNMCTSLAIRHTTHVPYNP
TSSGLVQRSNGILKTLLYKYFTDKPDLPMDNALSIALWTINHLNVLTNCH
KTRWQLHHSPRLQPIPETRSLSNKQTHWYYFKLPGLNSRQWKGPQEALQE
AAGAALIPVSASSAQWIPWRLLKRAA

3D structure

• PDB: 6voy Structural basis of host protein hijacking in human T-cell leukemia virus integration.
• Chain: A
• Resolution: 3.7 Å

Enzymatic activity

• Enzyme Commision number:
  2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	T23 R47 K94 E95 Q128	T24 R48 K95 E96 Q129
BS02	dna	A	N40 Q44	N41 Q45
BS03	dna	A	N121 Y147	N122 Y148
BS04	dna	A	Q156 K163	Q157 K164
BS05	dna	A	H49 I50 R51 T150 R157 L195 L220 A250 A251 G252 W265 R269	H50 I51 R52 T151 R158 L196 L221 A251 A252 G253 W266 R270
BS06	ZN	A	H6 H10 C33	H7 H11 C34
BS07	MG	A	D63 D120	D64 D121

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0004521 RNA endonuclease activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0015074 DNA integration

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6voy, PDBe:6voy, PDBj:6voy
• PDBsum: 6voy
• PubMed: 32561747
• UniProt: P14078;
  P39476|DN7D_SACS2 DNA-binding protein 7d (Gene Name=sso7d)