Structure of PDB 6vo2 Chain A

Receptor sequence

>6vo2A (length=326) Species: 1280 (Staphylococcus aureus)

TTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGIRPGR
SFDKAKEDGFDVFPVAEAVKQADVIMVLLPDEIQGDVYKNEIEPNLEKHN
ALAFAHGFNIHFGVIQPPADVDVFLVAPKGPGHLVRRTFVEGSAVPSLFG
IQQDASGQARNIALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGG
VSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYEGGMENVRYSIS
NTAEFGDYVSGPRVITPDVKENMKAVLTDIQNGNFSNRFIEDNKNGFKEF
YKLREEQHGHQIEKVGRELREMMPFI

3D structure

• PDB: 6vo2 Discovery, Synthesis and Evaluation of a Ketol-Acid Reductoisomerase Inhibitor.
• Chain: A
• Resolution: 1.59 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.86: ketol-acid reductoisomerase (NADP(+)).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	D190 E194	D189 E193
BS02	R67	A	E230 I250 S251 A254	E229 I249 S250 A253
BS03	NDP	A	Y25 G26 S27 Q28 I47 R48 S52 L79 L80 P81 D82 H107 P132	Y24 G25 S26 Q27 I46 R47 S51 L78 L79 P80 D81 H106 P131
BS04	R67	A	G131 P132 D190 E194	G130 P131 D189 E193
BS05	NDP	A	I250 S251	I249 S250

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004455 ketol-acid reductoisomerase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0050661 NADP binding

Biological Process

• GO:0008652 amino acid biosynthetic process
• GO:0009082 branched-chain amino acid biosynthetic process
• GO:0009097 isoleucine biosynthetic process
• GO:0009099 L-valine biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:6vo2, PDBe:6vo2, PDBj:6vo2
• PDBsum: 6vo2
• PubMed: 32198779
• UniProt: Q2FWK4|ILVC_STAA8 Ketol-acid reductoisomerase (NADP(+)) (Gene Name=ilvC)