Structure of PDB 6vno Chain A

Receptor sequence
>6vnoA (length=1084) Species: 9606 (Homo sapiens) [Search protein sequence]
VPYNRMKLMIVGNTGSGKTTLLQQLMGIDVKDWPILVLNVWDFAGREEFY
STHPRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVS
DEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINE
SLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLV
RENQLQLDENELPHAVHFLNESGVLLHFQALQLSDLYFVEPKWLCKIMAQ
ILTVGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLV
PSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYM
LLRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCI
LLGQVVDHIDSLMEEWFPGLLLLKKWALYSFNDGEEHQKILLDDLMKKAE
EGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLL
GDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISL
LAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYL
HSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGPGFRAPEVARGNVIYN
QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGC
APWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVI
VECMVATHHASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALV
HLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNFLLV
GTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESNVMWGGCGT
KIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSP
VVEVWDKKTEKLCGLIDCVHFLREVMMSYSGRVKTLCLQKNTALWIGTGG
GHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNREIQS
CLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTS
3D structure
PDB6vno Structure of LRRK2 in Parkinson's disease and model for microtubule interaction.
ChainA
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1994 H1998 N1999 D2017
Catalytic site (residue number reindexed from 1) D609 H613 N614 D632
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G1344 S1345 G1346 K1347 T1348 T1349 H1453 D1455 N1489 A1490 T1491 G15 S16 G17 K18 T19 T20 H96 D98 N132 A133 T134
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6vno, PDBe:6vno, PDBj:6vno
PDBsum6vno
PubMed32814344
UniProtQ5S007|LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (Gene Name=LRRK2)

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