Structure of PDB 6vn6 Chain A

Receptor sequence
>6vn6A (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
SKKHTGYVGLKNTCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLA
LQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVEN
KMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKN
IFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRF
MYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGD
NHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGTNAYMLVYIR
ESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKR
3D structure
PDB6vn6 Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.
ChainA
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R4J A M292 H294 D295 V296 Q297 Q351 L406 M407 R408 F409 H456 N460 Y465 Y514 M83 H85 D86 V87 Q88 Q142 L197 M198 R199 F200 H247 N251 Y256 Y294
BS02 ZN A C300 D349 H403 C91 D140 H194
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6vn6, PDBe:6vn6, PDBj:6vn6
PDBsum6vn6
PubMed32302140
UniProtQ93009|UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (Gene Name=USP7)

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