Structure of PDB 6vjw Chain A

Receptor sequence
>6vjwA (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPS
AEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGI
GKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHE
3D structure
PDB6vjw Catalytic mechanism of the mismatch-specific DNA glycosylase methyl-CpG-binding domain 4.
ChainA
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A L466 N467 R468 G536 G538 Y540 G541 D560 K562 L29 N30 R31 G99 G101 Y103 G104 D123 K125
BS02 dna A R468 K504 P505 G507 L508 Y509 D510 L511 R31 K67 P68 G70 L71 Y72 D73 L74
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6vjw, PDBe:6vjw, PDBj:6vjw
PDBsum6vjw
PubMed32297632
UniProtO95243|MBD4_HUMAN Methyl-CpG-binding domain protein 4 (Gene Name=MBD4)

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