Structure of PDB 6vjb Chain A

Receptor sequence
>6vjbA (length=1346) Species: 1314 (Streptococcus pyogenes) [Search protein sequence]
SLPPVNTDVHDWVKTKGAWDKGYKGQGKVVAVIATGIDPAHQSMRISDVS
TAKVKSKEDMLARQKAAGINYGSWINDKVVFAHNYVENSDNIKENQDTKY
ESHGMHVTGIVAGNSKEAAATGERFLGIAPEAQVMFMRVFANDIMGSAES
LFIKAIEDAVALGADVINLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVV
VAAGNERVYGSDHDDPLATNPDYGLVGSPSTGRTPTSVAAINSKWVIQRL
MTVKELENRADLNHGKAIYSESVDFKDIKDSLGQFAYVKESTDAGIALIE
RDPNKTYDEMIALAKKHGLGVLIFNNKPGQSNRSMRFISHEFGKAMSQLN
GNGTGSLEFDSVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGGDIY
STYNDNHYGSQTGTAMASPQIAGASLLVKQYLEKTQPNLPKEKIADIVKN
LLMSNAQIHVNPETKTTTSPRQQGAGLLNIDGAVTSGLYVTGKDNYGSIS
LGNITDTMTFDVTVHNLSNKDKTLRYDTELLTDHVDPQKGRFTLTSHSLK
TYQGGEVTVPANGKVTVRVTMDVSQFTKELTKQMPNGYYLEGFVRFRDSQ
DDQLNRVNIPFVGFKGQFENLAVAEESIYRLKSQGKTGFYFDESGPKDDI
YVGKHFTGLVTLGSETNVSTKTISDNGLHTLGTFKNADGKFILEKNAQGN
PVLAISPNGDNNQDFAAFKGVFLRKYQGLKASVYHASDKEHKNPLWVSPE
SFKGDKNFNSDIRFAKSTTLLGTAFSGKSLTGAELPDGHYHYVVSYYPDV
VGAKRQEMTFDMILDRQKPVLSQATFDPETNRFKPEPLKDRGLAGVRKDS
VFYLERKDNKPYTVTINDSYKYVSVEDNKTFVERQADGSFILPLDKAKLG
DFYYMVEDFAGNVAIAKLGDHLPTPIKLKLTDGNYQTKETLKDNLEMTQS
DTGLVTNQAQLAVVHRNQPQSQLTKMNQDFFISPNEDGNKDFVAFKNNVY
NDLTVNVYAKDDHQKQTPIWSSQAGASVSAIESTAWYGITARGSKVMPGD
YQYVVTEHQKQYTISVNDKKPMITQGRFDTINGVDHFTPDKTLDSSGIVR
EEVFYLAKKNGRKFDVTEGITVSDNKVYIPKNPDGSYTISKRDGVTLSDY
YYLVEDRAGNVSFATLRDLKAVGKDKAVVNFGLDLFTYLVRDADGKPIEN
LEYYNNSGNSLILPYGKYTVELLTYDTNAAKLESDKIVSFTLSADNNFQQ
VTFKITMLATSQITAHFDHLLPEGSRVSLKTAQDQLIPLEQSLYVPKAYG
KTVQEGTYEVVVSLPKGYRIEGNTKVNTLPNEVHELSLRLVKVGDA
3D structure
PDB6vjb Structure, dynamics and immunogenicity of a catalytically inactive CXC chemokine-degrading protease SpyCEP from Streptococcus pyogenes.
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.110: C5a peptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A S1190 N1192 D1194 N1196 K1197 D1198 S983 N985 D987 N989 K990 D991
BS02 CA A S908 N910 D912 N914 D916 S706 N708 D710 N712 D714
BS03 CA A D1017 Q1019 D1042 R1043 D1110 D815 Q817 D840 R841 D908
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005618 cell wall
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vjb, PDBe:6vjb, PDBj:6vjb
PDBsum6vjb
PubMed32257048
UniProtQ9A180

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