Structure of PDB 6vix Chain A

Receptor sequence
>6vixA (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]
HMEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMD
MSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDV
FEMRFAK
3D structure
PDB6vix Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
ChainA
Resolution2.116 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QYV A W374 P375 V380 D381 L385 N433 H437 V439 W25 P26 V31 D32 L36 N84 H88 V90 MOAD: Ki=1.3nM
BindingDB: Ki=22nM
External links
PDB RCSB:6vix, PDBe:6vix, PDBj:6vix
PDBsum6vix
PubMed32324999
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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