Structure of PDB 6viv Chain A

Receptor sequence
>6vivA (length=178) Species: 655278 (Influenza A virus (A/Luxembourg/43/2009(H1N1))) [Search protein sequence]
GSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAATCTHLEVCFM
YSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENR
FIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEE
SRARIKTRLFTIRQEMASRSLWDSFRQS
3D structure
PDB6viv Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
ChainA
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QZM A T38 H41 E119 I120 K134 T41 H44 E103 I104 K118
BS02 QQ4 A M12 F46 I78 M15 F49 I62
BS03 MN A H41 D108 E119 I120 H44 D92 E103 I104
BS04 MN A E80 D108 E64 D92
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6viv, PDBe:6viv, PDBj:6viv
PDBsum6viv
PubMed36603507
UniProtC6H0Y9

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