Structure of PDB 6vhg Chain A

Receptor sequence
>6vhgA (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
DAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVA
VKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEY
AKYGSLRGFLRESRRALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARN
ILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYT
TQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEE
MYRLMLQCWKQEPDKRPVFADISKDLEKMMVKR
3D structure
PDB6vhg Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.
ChainA
Resolution2.303 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D874 R878 N879 D892
Catalytic site (residue number reindexed from 1) D145 R149 N150 D163
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QX1 A L730 F735 V738 A756 K758 E775 V804 A807 G810 R878 L881 S891 D892 L24 F29 V32 A50 K52 E69 V98 A101 G104 R149 L152 S162 D163 MOAD: ic50=5.5uM
BindingDB: IC50=31nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6vhg, PDBe:6vhg, PDBj:6vhg
PDBsum6vhg
PubMed32292564
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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