Structure of PDB 6vh3 Chain A

Receptor sequence
>6vh3A (length=300) Species: 1335626 (Middle East respiratory syndrome-related coronavirus) [Search protein sequence]
HHSGLVKMSHPSGDVEACMVQVTCGSMTLNGLWLDNTVWCPRHVMCPADQ
LSDPNYDALLISMTNHSFSVQKHNLRVVGHAMQGTLLKLTVDVANPSTPA
YTFTTVKPGAAFSVLACYNGRPTGTFTVVMRPNYTIKGSFLCGSCGSVGY
TKEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTDKYC
SVNVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQSVDM
LAVKTGVAIEQLLYAIQQLYTGFQGKQILGSTMLEDEFTPEDVNMQIMGV
3D structure
PDB6vh3 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QYS A H41 F143 C148 H166 Q167 M168 E169 L170 A171 D190 Q192 V193 H194 Q195 H43 F140 C145 H163 Q164 M165 E166 L167 A168 D187 Q189 V190 H191 Q192
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6vh3, PDBe:6vh3, PDBj:6vh3
PDBsum6vh3
PubMed32747425
UniProtT2B9U0

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