Structure of PDB 6vgh Chain A

Receptor sequence
>6vghA (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRSMMGLLTNLADRELVHMINWA
KRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLD
RNQGKSGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTL
KSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRH
MSNKGMEHLYNVVPLSDLLLEMLDAHRLH
3D structure
PDB6vgh Ligand Binding Domain
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C3D A M343 L346 T347 A350 D351 E353 W383 L384 F404 M421 I424 L525 M32 L35 T36 A39 D40 E42 W72 L73 F93 M108 I111 L209 BindingDB: IC50=4nM,EC50=3.1nM
External links
PDB RCSB:6vgh, PDBe:6vgh, PDBj:6vgh
PDBsum6vgh
PubMed
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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