Structure of PDB 6vge Chain A

Receptor sequence
>6vgeA (length=98) Species: 9606 (Homo sapiens) [Search protein sequence]
MPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPH
3D structure
PDB6vge Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.
ChainA
Resolution4.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R367 R370 Y371 Y373 K380 K384 Y386 R63 R66 Y67 Y69 K76 K80 Y82
BS02 dna A Q312 W351 K355 K357 M360 K364 R367 A368 Y371 Y372 Q8 W47 K51 K53 M56 K60 R63 A64 Y67 Y68
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:6vge, PDBe:6vge, PDBj:6vge
PDBsum6vge
PubMed33275876
UniProtP11308|ERG_HUMAN Transcriptional regulator ERG (Gene Name=ERG)

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