Structure of PDB 6vff Chain A

Receptor sequence

>6vffA (length=382) Species: 9606 (Homo sapiens)

LPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKV
ISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNK
DDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEEPA
DRHPNRKARGQLRTKIESGQGTIPVRSNASIQTWDGVLQGERLLTMSCSD
KIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIE
DLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGK
DELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAKEY
QAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT

3D structure

• PDB: 6vff Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 3.5.4.37: double-stranded RNA adenine deaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	T375 K376 H394 E396 C451 R455 H460 H471 N473 R474 K475 S486 G487 Q488 C516	T57 K58 H76 E78 C133 R137 H142 H153 N155 R156 K157 S168 G169 Q170 C198
BS02	rna	A	I456 F457 R474 R477 R481 G487 Q488 I491 P492 R510	I138 F139 R156 R159 R163 G169 Q170 I173 P174 R192
BS03	IHP	A	R401 K519 R522 S531 K629 Y658 K662 Y668 K672 K690	R83 K201 R204 S213 K311 Y340 K344 Y350 K354 K372
BS04	ZN	A	H394 C451 C516	H76 C133 C198

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004000 adenosine deaminase activity

Biological Process

• GO:0006396 RNA processing

External links

• PDB: RCSB:6vff, PDBe:6vff, PDBj:6vff
• PDBsum: 6vff
• PubMed: 32597966
• UniProt: P78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)