Structure of PDB 6vdl Chain A

Receptor sequence
>6vdlA (length=200) Species: 11104 (Hepatitis C virus (isolate 1)) [Search protein sequence]
GSHMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQV
EGEVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVD
KDLVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSP
RPISYLKGSSGGPLLCPAGHAVGIFRTAVCTRGVAKAVDFIPVESLETTM
3D structure
PDB6vdl RAS at position 156 of HCV NS3/4A protease abolish inhibition by current HCV drugs
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1097 C1099 C1145 H1149 C118 C120 C166 H170
BS02 O31 A Q1041 H1057 D1081 L1135 G1137 S1139 F1154 R1155 T1156 A1157 Q62 H78 D102 L156 G158 S160 F175 R176 T177 A178
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6vdl, PDBe:6vdl, PDBj:6vdl
PDBsum6vdl
PubMed
UniProtP26664|POLG_HCV1 Genome polyprotein

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