Structure of PDB 6vcv Chain A

Receptor sequence
>6vcvA (length=111) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
MGVTKELKSPGNGVDFPKKGDFVTIHYTGRLTDGSKFDSSVDRNEPFQTQ
IGTGRVIKGWDEGVPQMSLGEKAVLTITPDYGYGARGFPPVIPGNSTLIF
EVELLGINNKR
3D structure
PDB6vcv Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y27 F37 D38 I57 Y83 F100
Catalytic site (residue number reindexed from 1) Y27 F37 D38 I57 Y83 F100
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R27 A Y27 F37 D38 F47 R55 V56 I57 W60 Y83 F88 Y27 F37 D38 F47 R55 V56 I57 W60 Y83 F88
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:6vcv, PDBe:6vcv, PDBj:6vcv
PDBsum6vcv
PubMed34809463
UniProtQ4WLV6|FKB1A_ASPFU FK506-binding protein 1A (Gene Name=fpr1A)

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