Structure of PDB 6vcq Chain A

Receptor sequence
>6vcqA (length=158) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
IDDDGYRPNVGIVICNRQGQVMWARRFGQHSWQFPQGGINPGESAEQAMY
RELFEEVGLSRKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQKWFL
LQLVSGDAEINMQTSSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMAAF
ASVVMSLQ
3D structure
PDB6vcq Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A R27 S32 Q37 Y77 L83 Q95 V137 K140 R26 S31 Q36 Y76 L82 Q94 V136 K139 MOAD: ic50=1578uM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005515 protein binding
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0034353 mRNA 5'-diphosphatase activity
GO:0110153 RNA NAD-cap (NMN-forming) hydrolase activity
Biological Process
GO:0006402 mRNA catabolic process
GO:0008033 tRNA processing
GO:0050779 RNA destabilization
GO:0110154 RNA decapping
GO:0110155 NAD-cap decapping
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:6vcq, PDBe:6vcq, PDBj:6vcq
PDBsum6vcq
PubMed31960065
UniProtP0A776|RPPH_ECOLI RNA pyrophosphohydrolase (Gene Name=rppH)

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