Structure of PDB 6vc8 Chain A

Receptor sequence
>6vc8A (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSED
VPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYT
LVREIRKHKE
3D structure
PDB6vc8 Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A G12 G13 V14 G15 K16 S17 A18 F28 D30 Y32 P34 T35 K117 D119 L120 S145 A146 K147 G12 G13 V14 G15 K16 S17 A18 F28 D30 Y32 P34 T35 K109 D111 L112 S137 A138 K139
BS02 MG A S17 T35 S17 T35
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:6vc8, PDBe:6vc8, PDBj:6vc8
PDBsum6vc8
PubMed34983849
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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