Structure of PDB 6vc2 Chain A

Receptor sequence
>6vc2A (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
SIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMA
DQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGK
EGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFV
CLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQL
LLRLPEIRAISMQAEEYLYYKHLNGDVNLLIEMLHA
3D structure
PDB6vc2 Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist.
ChainA
Resolution1.697 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F354 R361 D372 Q374 M375 L531 E534 F55 R62 D73 Q75 M76 L229 E232
BS02 QU7 A F342 M345 C346 S383 L386 I387 H390 L405 L424 L427 L517 F43 M46 C47 S84 L87 I88 H91 L106 L125 L128 L218 MOAD: Ki=1.2uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:6vc2, PDBe:6vc2, PDBj:6vc2
PDBsum6vc2
PubMed33335203
UniProtO00482|NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Gene Name=NR5A2)

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