Structure of PDB 6v9c Chain A

Receptor sequence
>6v9cA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPLDPLWEFPRDRLVLGKPLGEGQVVRAEAFGMDPARPDQASTVAVKML
KDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAK
GNLREFLRARRPPSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAAR
NVLVTEDNVMKIADFGLIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDV
WSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLM
RECWHAAPSQRPTFKQLVEALDKVLLAVS
3D structure
PDB6v9c Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D612 R616 N617 D630
Catalytic site (residue number reindexed from 1) D146 R150 N151 D164
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QS7 A V481 R483 T499 K503 E520 M524 V550 C552 A553 G556 L619 A629 D630 V26 R28 T44 K48 E65 M69 V95 C97 A98 G101 L153 A163 D164 BindingDB: IC50=<100nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6v9c, PDBe:6v9c, PDBj:6v9c
PDBsum6v9c
PubMed33062171
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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