Structure of PDB 6v8u Chain A

Receptor sequence

>6v8uA (length=120) Species: 9606 (Homo sapiens) [Search protein sequence]

DDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKV
FPLAEYRTKHEIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGD
SKLYRLHPCRSLQIRQYAYL

3D structure

PDB

6v8u A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences.

Chain

Resolution

2.103 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Y503 V504 S508 R511 E535 Y536 Q563 R595 Q596 Y597 A598	Y23 V24 S28 R31 E55 Y56 Q83 R115 Q116 Y117 A118
BS02	dna	A	K520 Y522 A534 E535 T538 R549 Y550 Y562 Q563 S578 Y584 L586 R595 Y597 Y599	K40 Y42 A54 E55 T58 R69 Y70 Y82 Q83 S98 Y104 L106 R115 Y117 Y119
BS03	ZN	A	C496 C499 H512 H516	C16 C19 H32 H36
BS04	ZN	A	C524 C527 H540 H544	C44 C47 H60 H64
BS05	ZN	A	C552 C555 H568 H573	C72 C75 H88 H93

External links

PDB	RCSB:6v8u, PDBe:6v8u, PDBj:6v8u
PDBsum	6v8u
PubMed	32352758
UniProt	Q86T24\|KAISO_HUMAN Transcriptional regulator Kaiso (Gene Name=ZBTB33)