Structure of PDB 6v8t Chain A

Receptor sequence
>6v8tA (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
MALSLTADQMVSALLDAEPPILYSEYASMMGLLTNLADRELVHMINWAKR
VPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRN
QGEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFKDHIH
RVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLY
SSDLLLEMLD
3D structure
PDB6v8t Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C6V A L346 T347 A350 E353 L387 F404 I424 G521 L525 L33 T34 A37 E40 L74 F91 I108 G195 L199 BindingDB: IC50=6.0nM
External links
PDB RCSB:6v8t, PDBe:6v8t, PDBj:6v8t
PDBsum6v8t
PubMed35575456
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]