Structure of PDB 6v8n Chain A

Receptor sequence
>6v8nA (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
FSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKP
GMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPP
PNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWA
CPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIF
KQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQKTSKNKSSNDLSQKL
YATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLA
RDKHLEFSSLRRAQWSTGCMLVELHTQ
3D structure
PDB6v8n Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.
ChainA
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QS1 A L1398 D1399 S1400 Y1414 P1440 G1443 D1444 Y1446 H1451 Q1455 I1457 P1458 L1463 W1466 L111 D112 S113 Y127 P153 G156 D157 Y159 H164 Q168 I170 P171 L176 W179 BindingDB: IC50=<0.500000nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6v8n, PDBe:6v8n, PDBj:6v8n
PDBsum6v8n
PubMed32181984
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

[Back to BioLiP]