Structure of PDB 6v8a Chain A

Receptor sequence
>6v8aA (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
HMPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALM
YHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASV
EETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGE
TLGIIGLGRTGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQD
LLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKAL
AQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASI
EMREEAAREIRRAITGRIPDSLKNCVNKDHLT
3D structure
PDB6v8a NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A G181 G183 R184 Y203 D204 Y206 C237 N243 G156 G158 R159 Y178 D179 Y181 C212 N218
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:6v8a, PDBe:6v8a, PDBj:6v8a
PDBsum6v8a
PubMed33524397
UniProtQ13363|CTBP1_HUMAN C-terminal-binding protein 1 (Gene Name=CTBP1)

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