Structure of PDB 6v6z Chain A

Receptor sequence
>6v6zA (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
GRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLL
YAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGH
IYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYA
VGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGG
YDGQDQLNSVERYDVATATWTFVAPMKHRRSALGITVHQGRIYVLGGYDG
HTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
3D structure
PDB6v6z Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 Q5Y A Y334 S363 G364 R415 S508 G509 Y525 S555 Y572 F577 S602 G603 Y10 S39 G40 R91 S184 G185 Y201 S231 Y248 F253 S278 G279 MOAD: ic50=63nM
BindingDB: IC50=110nM
External links
PDB RCSB:6v6z, PDBe:6v6z, PDBj:6v6z
PDBsum6v6z
PubMed32292559
UniProtQ14145|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Gene Name=KEAP1)

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