Structure of PDB 6v5k Chain A

Receptor sequence

>6v5kA (length=427) Species: 9606 (Homo sapiens) [Search protein sequence]

MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

PDB

6v5k Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP*

Chain

Resolution

2.69 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	S113 E116 S257 G259 G260 K261 L262 R377 L381 R382 R383 C384	S113 E116 S252 G254 G255 K256 L257 R372 L376 R377 R378 C379
BS02	dna	A	Q38 Y39 W42 G46 S62 K86 K311 R313 P316 K317 T318 G320 S322 K323 N324 P326 G327 R351	Q38 Y39 W42 G46 S62 K86 K306 R308 P311 K312 T313 G315 S317 K318 N319 P321 G322 R346
BS03	0KX	A	M14 C16 F18 Y52 R55 R61 D115 K231	M14 C16 F18 Y52 R55 R61 D115 K226
BS04	MN	A	D13 M14 D115	D13 M14 D115

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6v5k, PDBe:6v5k, PDBj:6v5k
PDBsum	6v5k
PubMed
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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