Structure of PDB 6v3k Chain A

Receptor sequence
>6v3kA (length=259) Species: 11698,273057 [Search protein sequence]
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAM
HGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYF
LLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGV
IESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERI
VDIIATDIQTKELQKQITKIQNFRVYYGPAKLLWKGEGAVVIQDNSDIKV
VPRRKAKII
3D structure
PDB6v3k Structural basis for strand-transfer inhibitor binding to HIV intasomes.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A H51 G52 Q53 V54 G140 I141 Q146 S147 G149 S153 H51 G52 Q53 V54 G140 I141 Q146 S147 G149 S153
BS02 dna A E152 K156 E152 K156
BS03 MG A D64 D116 D64 D116
BS04 MG A D64 E152 D64 E152
BS05 ZN A H12 H16 C40 C43 H12 H16 C40 C43
BS06 QUW A D64 D116 Y143 P145 Q146 E152 D64 D116 Y143 P145 Q146 E152
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004521 RNA endonuclease activity
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:6v3k, PDBe:6v3k, PDBj:6v3k
PDBsum6v3k
PubMed32001521
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol);
P39476|DN7D_SACS2 DNA-binding protein 7d (Gene Name=sso7d)

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