Structure of PDB 6v3h Chain A

Receptor sequence
>6v3hA (length=1232) Species: 10116 (Rattus norvegicus) [Search protein sequence]
LYTPKHEAGVCTFYEECGKNPELSGGLTSLSNVSCLSNTPARHVTGEHLA
LLQRICPRLYNGPNTTFACCSTKQLLSLESSMSITKALLTRCPACSDNFV
SLHCHNTCSPDQSLFINVTRVVERGAGEPPAVVAYEAFYQRSFAEKAYES
CSQVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFH
LLEPGQALPDGIQPLNGKIAPCNESQGDDSAVCSCQDCAASCPVIPPPEA
LRPSFYMGRMPGWLALIIIFTAVFVLLSAVLVRLRVVSNRNKSPHTILGR
FFQNWGTRVASWPLTVLALSFIVVIALAAGLTFIELTTDPVELWSAPKSQ
ARKEKSFHDEHFGPFFRTNQIFVTARNRSSYKYDSLLLGSKNFSGILSLD
FLLELLELQERLRHLQVWSPEAERNISLQDICYAPLNPYNTSLSDCCVNS
LLQYFQNNRTLLMLTANQTLNGQTSLVDWKDHFLYCANAPLTFKDGTSLA
LSCMADYGAPVFPFLAVGGYQGTDYSEAEALIITFSLNNYPADDPRMAQA
KLWEEAFLKEMESFQRNTSDKFQVAFSAERSLEDEINRTTIQDLPVFAVS
YIIVFLYISLALGSYSRCSRVAVESKATLGLGGVIVVLGAVLAAMGFYSY
LGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQREAHIGRT
LGSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAIILDFLLQMT
AFVALLSLDSKRQEASRPDVLCCKEGLLLRFFRKIYAPFLLHRFIRPVVM
LLFLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPV
YFVTTSGFNFSSEAGMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAA
SSWVDDFIDWLTPSSSCCRLYIRGPHKDEFCPSTDTSFNCLKNCMNRTLG
PVRPTAEQFHKYLPWFLNDPPNIRCPKGGLAAYRTSVNLSSDGQVIASQF
MAYHKPLRNSQDFTEALRASRLLAANITADLRKVPGTDPNFEVFPYTISN
VFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDMCSGILNLLSIIMIL
VDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLE
RAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLL
GLLHGLVFLPVVLSYLGPDVNQALVQEEKLAS
3D structure
PDB6v3h Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A L633 A637 L594 A598
BS02 QO1 A S187 L213 P474 L475 L530 F532 G547 A548 P1021 N1022 A1031 S166 L192 P435 L436 L491 F493 G508 A509 P971 N972 A981 BindingDB: IC50=4nM
Gene Ontology
Molecular Function
GO:0005319 lipid transporter activity
GO:0008431 vitamin E binding
GO:0015485 cholesterol binding
GO:0031267 small GTPase binding
GO:0031489 myosin V binding
GO:0042803 protein homodimerization activity
GO:1901363 heterocyclic compound binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0014850 response to muscle activity
GO:0030299 intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0042157 lipoprotein metabolic process
GO:0042360 vitamin E metabolic process
GO:0042632 cholesterol homeostasis
GO:0051180 vitamin transport
GO:0070508 cholesterol import
GO:0071501 cellular response to sterol depletion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6v3h, PDBe:6v3h, PDBj:6v3h
PDBsum6v3h
PubMed
UniProtQ6T3U3|NPCL1_RAT NPC1-like intracellular cholesterol transporter 1 (Gene Name=Npc1l1)

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