Structure of PDB 6v37 Chain A

Receptor sequence

>6v37A (length=263) Species: 10090 (Mus musculus)

NVMKWKTVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQREKFLR
AHPCVSDQELDELIQQIVAADNASHWDLGSSFFFAGTVITTIGFGNISPR
TEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFQTKIR
IISTIIFILFGCVLFVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDY
VAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVIAKKTKEAV
GEFRAHAAEWTAN

3D structure

• PDB: 6v37 Polynuclear Ruthenium Amines Inhibit K2PChannels via a "Finger in the Dam" Mechanism.
• Chain: A
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Q6F	A	H126 S131 F134 T138 A259 G260 K271 W275 I278	H75 S80 F83 T87 A202 G203 K214 W218 I221
BS02	K	A	I143 G144 F145 I252 G253 F254	I92 G93 F94 I195 G196 F197
BS03	K	A	T142 I143 T251 I252 G253	T91 I92 T194 I195 G196
BS04	K	A	G144 F145 G146 G253 F254 G255	G93 F94 G95 G196 F197 G198
BS05	K	A	T142 T251	T91 T194

Gene Ontology

Molecular Function

• GO:0005267 potassium channel activity

Biological Process

• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6v37, PDBe:6v37, PDBj:6v37
• PDBsum: 6v37
• PubMed: 32059793
• UniProt: P97438|KCNK2_MOUSE Potassium channel subfamily K member 2 (Gene Name=Kcnk2)