Structure of PDB 6v2m Chain A

Receptor sequence
>6v2mA (length=531) Species: 562 (Escherichia coli) [Search protein sequence]
EELEAYGISDVHDIVYNPSYDLLYQEELDPSLTGYERGVLTNLGAVAVDT
GIFTGRSPKDKYIVRDDTTRDTFWWADKGKGKNDNKPLSPETWQHLKGLV
TRQLSGKRLFVVDAFCGANPDTRLSVRFITEVAWQAHFVKNMFIRPSDEE
LAGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERMQLIGGTWYGG
EMKKGMFSMMNYLLPLKGIASMHCSANVGEKGDVAVFFGLSGTGKTTLST
DPKRRLIGDNEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYNAIRRDAL
LENVTKREDGTIDFDDGSKTENTRVSYPIYHIDNIVKPVSKAGHATKVIF
LTADAFGVLPPVSRLTADQTQYHFLSGFTAKLAGTERGITEPTPTFSACF
GAAFLSLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAII
DAILNGSLDNAETFTLPMFNLAIPTELPGVDTKILDPRNTYASPEQWQEK
AETLAKLFIDNFDKYTDTPAGAALVAAGPKL
3D structure
PDB6v2m Kinetic and structural analysis of Escherichia coli phosphoenolpyruvate carboxykinase mutants.
ChainA
Resolution1.66 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R65 K213 H232 S250 K254 T255 N269 R333
Catalytic site (residue number reindexed from 1) R56 K204 H223 S241 K245 T246 N260 R324
Enzyme Commision number 4.1.1.49: phosphoenolpyruvate carboxykinase (ATP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A S250 G251 G253 K254 T255 T256 K288 R333 R449 I452 T455 S241 G242 G244 K245 T246 T247 K279 R324 R440 I443 T446
BS02 MG A T255 Y286 T246 Y277
BS03 CA A H232 S250 H223 S241
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004611 phosphoenolpyruvate carboxykinase activity
GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0016831 carboxy-lyase activity
GO:0017076 purine nucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0006094 gluconeogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:6v2m, PDBe:6v2m, PDBj:6v2m
PDBsum6v2m
PubMed31911238
UniProtP22259|PCKA_ECOLI Phosphoenolpyruvate carboxykinase (ATP) (Gene Name=pckA)

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