Structure of PDB 6v2l Chain A

Receptor sequence
>6v2lA (length=532) Species: 562 (Escherichia coli) [Search protein sequence]
PQELEAYGISDVHDIVYNPSYDLLYQEELDPSLTGYERGVLTNLGAVAVD
TGIFTGRSPKDKYIVRDDTTRDTFWWADKGKGKNDNKPLSPETWQHLKGL
VTRQLSGKRLFVVDAFCGANPDTRLSVRFITEVAWQAHFVKNMFIRPSDE
ELAGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERMQLIGGTWYG
GEMKKGMFSMMNYLLPLKGIASMHCSANVGEKGDVAVFFGLAGTGKTTLS
TDPKRRLIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYNAIRRDA
LLENVTVREDGTIDFDDGSKTENTRVSYPIYHIDNIVKPVSKAGHATKVI
FLTADAFGVLPPVSRLTADQTQYHFLSGFTAKLAGTERGITEPTPTFSAC
FGAAFLSLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAI
IDAILNGSLDNAETFTLPMFNLAIPTELPGVDTKILDPRNTYASPEQWQE
KAETLAKLFIDNFDKYTDTPAGAALVAAGPKL
3D structure
PDB6v2l Kinetic and structural analysis of Escherichia coli phosphoenolpyruvate carboxykinase mutants.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R65 K213 H232 A250 K254 T255 D269 R333
Catalytic site (residue number reindexed from 1) R57 K205 H224 A242 K246 T247 D261 R325
Enzyme Commision number 4.1.1.49: phosphoenolpyruvate carboxykinase (ATP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A H232 A250 G251 G253 K254 T255 T256 K288 E297 R333 T441 R449 S451 I452 T455 H224 A242 G243 G245 K246 T247 T248 K280 E289 R325 T433 R441 S443 I444 T447
BS02 ACT A L249 A250 F413 L241 A242 F405
BS03 MN A K213 H232 D269 K205 H224 D261
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004611 phosphoenolpyruvate carboxykinase activity
GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0016831 carboxy-lyase activity
GO:0017076 purine nucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0006094 gluconeogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6v2l, PDBe:6v2l, PDBj:6v2l
PDBsum6v2l
PubMed31911238
UniProtP22259|PCKA_ECOLI Phosphoenolpyruvate carboxykinase (ATP) (Gene Name=pckA)

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