Structure of PDB 6v2e Chain A

Receptor sequence

>6v2eA (length=555) Species: 9606,83333 [Search protein sequence]

KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTNAAAEFGGTVKNYETAVQFCWNHYKDQMDPIEKD
WCDWAMISRPYSTLRDCLEHFAERFDLGFPNPLAERIIFETHQIHFANCS
LVQPTFSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLC
WNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNY
TQCNV

3D structure

PDB

6v2e Picomolar Affinity Antagonist and Sustained Signaling Agonist Peptide Ligands for the Adrenomedullin and Calcitonin Gene-Related Peptide Receptors.

Chain

Resolution

1.83 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Q154 R356 R1097 E1101 T2037 D2070 W2072 D2090 Y2091 F2092 Q2093 D2094 H2114 A2116 S2117 R2119 W2121 T2122	Q152 R354 R415 E419 T463 D496 W498 D516 Y517 F518 Q519 D520 H540 A542 S543 R545 W547 T548
BS02	GLC	A	D16 K17 E113 E155 W232	D14 K15 E111 E153 W230
BS03	GLC	A	W64 D67 R68 E155 P156 Y157 W342 R346	W62 D65 R66 E153 P154 Y155 W340 R344

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0015026	coreceptor activity
GO:0015144	carbohydrate transmembrane transporter activity

	Biological Process
GO:0006886	intracellular protein transport
GO:0007186	G protein-coupled receptor signaling pathway
GO:0008277	regulation of G protein-coupled receptor signaling pathway
GO:0008643	carbohydrate transport
GO:0055085	transmembrane transport

	Cellular Component
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:6v2e, PDBe:6v2e, PDBj:6v2e
PDBsum	6v2e
PubMed	32832875
UniProt	O60895\|RAMP2_HUMAN Receptor activity-modifying protein 2 (Gene Name=RAMP2); P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q16602\|CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (Gene Name=CALCRL)

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