Structure of PDB 6uza Chain A

Receptor sequence
>6uzaA (length=734) Species: 9606 (Homo sapiens) [Search protein sequence]
AYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQ
NALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHP
AFAEGKRLATQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKG
ARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSED
PVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEV
EAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWY
ENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMK
FVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFS
WMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFI
ARFMAFWHASKAQSIIDKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAI
AVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIG
MFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIE
NIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWF
SYFEEGRTLPVPFNLVRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKE
IKQDISSLRYELLEEKSQNTEDLAELIRELGEKL
3D structure
PDB6uza Structural basis for pharmacological modulation of the TRPC6 channel.
ChainA
Resolution3.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R0G A H446 E509 E512 R609 Y612 I613 S752 Y753 R758 H354 E417 E420 R508 Y511 I512 S651 Y652 R657
BS02 S9Y A W526 A611 Q624 W434 A510 Q523
BS03 Y01 A W391 Y392 F407 N617 W299 Y300 F315 N516
BS04 Y01 A F699 N702 I703 F598 N601 I602
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0042803 protein homodimerization activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006812 monoatomic cation transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007338 single fertilization
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051928 positive regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex
GO:0036057 slit diaphragm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uza, PDBe:6uza, PDBj:6uza
PDBsum6uza
PubMed32149605
UniProtQ9Y210|TRPC6_HUMAN Short transient receptor potential channel 6 (Gene Name=TRPC6)

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